College football odds, picks, lines for Week 12: Advanced computer model loving Ohio State, Wisconsin

Alabama, Clemson, Michigan and Georgia are all heavily favored in the latest Week 12 college football odds, but Saturday is a prime opportunity for teams on the outside of the College Football Playoff picture to make a statement. No. 7 West Virginia is a 5.5-point favorite for a trip to Oklahoma State. No. 11 Central Florida is favored by a touchdown against Cincinnati, while No. 8 Washington State is a 10.5-point favorite against Arizona as the Cougars look to remain the Pac-12's only playoff hope. With just two weeks remaining in the regular season and college football odds and lines of all sizes, be sure to check out the Week 12 college football picks and predictions from SportsLine's proven computer model. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen massive returns. Over the past three years, this proprietary computer model has generated a jaw-dropping $4,210 profit for $100 bettors on its top-rated point-spread picks. 

The model was red-hot on top-rated picks last week. It nailed Ohio State (-3.5) over Michigan State in a game where the Buckeyes covered with plenty of room to spare in a 26-6 rout. Plays like that helped it go an impressive 23-10 overall on all top-rated picks, and anyone who followed it finished way, way up. 

Now it has simulated every single play and its Week 12 college football picks are in. 

One of the Week 12 college football picks the model is recommending: No. 10 Ohio State (-14.5) covers at Maryland. 

Heading into Week 11, the Buckeyes had been sluggish, getting blown out by Purdue and then struggling in a tight win over Nebraska in their previous two games. But they broke out of that slump by blasting No. 18 Michigan State by 20 points in a game where the Spartans mustered just 12 first downs and 274 yards of total offense. 

The model projects that Ohio State will keep rolling this week against a Maryland squad that has lost three of its past four. A week after allowing 34 points to Indiana, the Terrapins will give up 330 passing yards to OSU quarterback Dwayne Haskins, according to the model. The Buckeyes pile up well over 200 yards on the ground as they cover in almost 70 percent of simulations.

Another one of the strong Week 12 college football predictions from the model: Wisconsin (+4) not only covers, but pulls off the outright upset at Purdue. 

It's been an eventful week for the Boilermakers with head coach Jeff Brohm heavily linked to the job opening at Louisville. Though he's denied any deal is in place, the reports and rumors could be a distraction for Purdue. 

Wisconsin quarterback Alex Hornibrook (concussion) is questionable, but the model projects him to play and put up close to 200 yards passing, while running back Jonathan Taylor goes off for 130 yards on the ground for the Badgers. Wisconsin covers in over 60 percent of simulations, while a pick on the Badgers' money line (+160) could pay off huge because that hits almost 55 percent of the time. 

The model also has made the call on the huge Shamrock Series game between No. 3 Notre Dame and No. 12 Syracuse at Yankee Stadium, and is projecting a team with College Football Playoff aspirations to get absolutely stunned by a big underdog. 

So what college football picks can you make with confidence in Week 12? And what playoff contender goes down hard? Check out the latest Week 12 college football odds below, and then visit SportsLine to see which teams are winning more than 50 percent of simulations, all from a proven computer model that has returned over $4,000 in profit over the past three seasons.

Penn State at Rutgers (+28, 49.5)
Middle Tennessee at Kentucky (-16.5, 46.5)
Ohio State at Maryland (+14.5, 58.5)
Arkansas at Mississippi State (-21.5, 46.5)
Michigan State at Nebraska (+1, 48)
NC State at Louisville (+16, 63.5)
Utah at Colorado (+7, 47.5)
Utah State at Colorado State (+28.5, 67)
Syracuse vs. Notre Dame (-10, 65)
Wisconsin at Purdue (-4, 52.5)
Missouri at Tennessee (+6.5, 57)
West Virginia at Oklahoma State (+5.5, 73.5)
Miami at Virginia Tech (+6, 51.5)
USC at UCLA (+3, 54.5)
Indiana at Michigan (-28.5, 53.5)
Massachusetts at Georgia (-41, 66.5)
Liberty at Auburn (-28.5, 62)
Oregon State at Washington (-33.5, 58.5)
Duke at Clemson (-28, 57.5)
Stanford at California (+2, 45)
Rice at LSU (-42, 52)
Ole Miss at Vanderbilt (-3, 70)
Kansas at Oklahoma (-35, 69)
Cincinnati at Central Florida (-7, 61)
Iowa State at Texas (-3, 47)
Arizona State at Oregon (-3.5, 64)
Arizona at Washington State (-10.5, 62.5)

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